CRC DEP Stick

Ingredients:
Palmitoylethanolamide (PEA, water-dispersible), Melatonin and others.

Properties:
CRC DEP is a nutraceutical formulation developed to support the modulation of neuroinflammation, promote physiological pain control, and improve sleep quality and circadian balance.
Palmitoylethanolamide (PEA):
PEA is an endogenous fatty acid amide belonging to the ALIAmide family (Autacoid Local Injury Antagonist amides). It exerts anti-inflammatory, analgesic, and neuroprotective effects by modulating non-neuronal cells such as mast cells and microglia.
PEA acts through the peroxisome proliferator-activated receptor-α (PPAR-α) and interacts with endocannabinoid signaling pathways, leading to a reduction in the release of pro-inflammatory mediators and hyperalgesia.
The water-dispersible form ensures enhanced bioavailability and rapid absorption, contributing to effective management of neuropathic pain, chronic inflammation, and neurogenic disorders.
Melatonin:
A neurohormone produced by the pineal gland, melatonin regulates the sleep–wake cycle and exerts antioxidant and anti-inflammatory effects. At low doses, it helps restore physiological circadian rhythm, improving sleep onset and quality without causing dependence.
Combined with PEA, melatonin synergistically enhances neuroprotective and anti-inflammatory actions, supporting nervous system recovery and overall well-being.

Indications:
CRC DEP is indicated for:

Neuropathic pain and chronic neuroinflammatory conditions
Adjunctive support in pain syndromes (e.g., fibromyalgia, sciatica, and nerve compression)
Neuroprotective support in conditions associated with microglial activation
Sleep disturbances related to chronic pain or neuroinflammation
Improving circadian rhythm and restoring physiological rest–wake balance